In 2151, the Klingon vessel IKS Somraw raided a Xarantine outpost and looted Xarantine ale to celebrate the victory. However, unknown to the Klingons, the ale was poisoned. Falling ill and being attacked by Xarantine ships, the commander of the Somraw eventually decided to retreat into a Q'tahL class gas giant's atmosphere. (ENT: "Sleeping Dogs")
The Xarantine are also mentioned in the Star Trek: A Time to... and Star Trek: Destiny novel series. In the Star Trek Online video game a "Xarantine system" within a "Xarantine sector" is located along the Federation-Klingon border next to the Archanis sector.