The Wright brothers, Orville (1871-1948) and Wilbur (1867-1912), were two Human brothers who were the first to invent aircraft controls that made fixed-wing powered flight possible.(ENT: "North Star")
On a failed Skagaran colony in the Delphic Expanse, the teacher Bethany educated Human and Skagaran children about the Wright Brothers' historic flight. (ENT: "North Star")
After Jonathan Archer restored a damaged timeline, the Wright Flyer could be seen in the time stream as the timeline realigned itself. (ENT: "Storm Front, Part II")
In 2372, before Lieutenant Tom Paris attempted the first transwarp flight by Humans, Captain Kathryn Janeway told him he would be joining an elite group of pilots, including Orville Wright. (VOY: "Threshold")
A scene featuring their historic flight is also featured in the opening credits for Star Trek: Enterprise.