Wise can refer to:

• The Wise Ones, the ancient race that saved the Amerind people
• D. Wise, a Starfleet commander in the 23rd century

It may also refer to the following production related staff:

• David Wise, script writer on The Animated Series
• Douglas E. Wise, assistant director on five of the first six movies
• Millicent Wise, wife of Robert Wise and an extra in the first movie
• Ray Wise, an actor who appeared in The Next Generation and Voyager in guest roles
• Robert Wise, director of Star Trek: The Motion Picture

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