The Vega-Omicron sector is a sector of space on the outer border of the Federation.

In 2365, the USS Aries picked up indications of intelligent lifeforms here, when the ship's captain retired and was due to be replaced by William T. Riker. Though he later declined, it would have taken him months at high warp from Starbase Montgomery to get to the Vega-Omicron sector. (TNG: "The Icarus Factor")