The USS Yukon was a Federation Danube-class runabout that was in service with Starfleet in the late 24th century, attached to Deep Space 9.
In 2372, Miles O'Brien and Major Kira Nerys were returning to DS9 aboard the Yukon when they witnessed the detonation of a cloaked Klingon mine. (DS9: "Sons of Mogh")
A year later, the Yukon was stolen by a Changeling impersonating Julian Bashir. The Changeling killed the runabout's crew and modified it to withstand the heat of the Bajoran sun. The Changeling also equipped the runabout with trilithium, tekasite, and protomatter, ingredients which would destroy the entire Bajoran system. The Yukon was being tractored away by the USS Defiant from the sun when the bomb exploded, destroying the ship. (DS9: "By Inferno's Light")
The Defiant tractors the Yukon