In a deleted scene from Star Trek Nemesis, the USS Talos, a Federation starship in service in the late 24th century, was stated as being the starship from which Commander Martin Madden transferred to become first officer of the USS Enterprise-E in 2379.

The ship was possibly meant as a reference to the Talos star group, one planet of which was Talos IV, a planet first visited in the first Star Trek pilot, "The Cage". It is also possibly named after Talos, the bronze automaton from Greek mythology.