The USS Sentinel was a Federation starship during the 24th century.
While visiting Deep Space 9 during the Dominion War in 2375, the Sentinel listed a surplus graviton stabilizer on its manifest. Nog, acting on behalf of Chief O'Brien who needed the stabilizer for the USS Defiant, secured the unit in a complicated trade that brought a phaser emitter from the USS Musashi. (DS9: "Treachery, Faith, and the Great River")
- The starship class of the Sentinel is not known, but the games Star Trek: Invasion and Star Trek: Armada portray it as a Sovereign-class vessel, while Pocket Books' Star Trek: SCE, War Stories, Book I states the vessel belongs to the Akira-class and that Lt. Commander Sonya Gomez served aboard the vessel during the Dominion War.