The USS Lalo was a Federation freighter that was in service with Starfleet in the mid-24th century.

Together with the farming colony on Coltar IV, the USS Lalo reported experiencing the Manheim Effect in 2364. The captain of the ship described the time distortion as a "hiccup." (TNG: "We'll Always Have Paris")

In late 2366, the USS Lalo was on a freight run from Zeta Alpha II to Sentinel Minor IV. A distress signal was received from the Lalo at Starbase 157 at 2212 hours, in which the ship reported being under attack from a vessel, described as "cube shaped." The signal ended abruptly, and it was believed that the ship had been destroyed by a Borg cube. (TNG: "The Best of Both Worlds")