Tuscany was a region in northern Italy on Earth. Among the region's cities were Siena and Florence.

Leonardo da Vinci and Galileo Galilei came from this region.

When Captain Janeway suffered from Srivani medical experiments causing her stress and sleeplessness, she wanted to relax by visiting Tuscany, more specifically a little inn near Siena on the holodeck she had always wanted to try. (VOY: "Scientific Method")