The Borg transwarp network was a vast series of transwarp conduits spanning the entire galaxy. The conduits were connected by six transwarp hubs, and were supported by a series of interspatial manifolds, which were protected by shielding regulated from the central nexus by the Borg Queen herself. The network maintained thousands of exit apertures in all four quadrants, allowing the Collective to deploy vessels almost anywhere in the Milky Way Galaxy within minutes, giving the Borg a decisive tactical advantage.

The transwarp network was destroyed in 2378 when Kathryn Janeway's counterpart from twenty-six years in the future was able to infect the Queen with a neurolytic pathogen, an act which interfered with the Queen's ability to regulate the shielding protecting the interspatial manifolds. This allowed the crew of the USS Voyager to fire a series of transphasic torpedoes, destroying the manifolds and causing the network to collapse. (VOY: "Endgame")