A thermolyte explosive is a type of powerful explosive.

In 2378, Commander Nocona and his team used thermolyte explosive charges to break apart asteroids for mining purposes. He later also used them in an attempt to stop a Talaxian colony from erecting a defensive shield around their home asteroid, though the Baxial and the Delta Flyer II were able to intercept most of them before they reached their targets. The explosives proved ineffective once the shield became active. (VOY: "Homestead")