A thermokinetic explosion is an extremely powerful energy discharge produced by some detonation weapons.

The mines encountered in 2152 by the crew of the Enterprise NX-01 surrounding a planet annexed by the Romulan Star Empire produced thermokinetic explosions with yields of approximately one-quarter of a kiloton. Just one of these explosions was sufficient to destroy a large portion of the ship's port-forward quarter. (ENT: "Minefield")