Starfleet Communications was the division of Starfleet responsible for subspace communications between its many vessels and starbases. The Communications Research Center was based in San Francisco on Earth. It was home to the Pathfinder Project during the late 2370s, which successfully developed major advances in extreme long range communications that allowed reestablishment of contact with the USS Voyager which was stranded out of touch in the galaxy's Delta Quadrant. The facility included several holodecks. (VOY: "Pathfinder")

As of 2377 its staff included Admiral Owen Paris, Commander Peter Harkins, and Lieutenant Reginald Barclay. (VOY: "Pathfinder", "Inside Man", "Endgame")