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The spleen was an organ of the body that acted primarily as a blood filter.

Strain on the spleen was one of the side-effects of an experimental chemical stimulant designed to speed up reproduction and replacement of blood used in the mid-2260s. (TOS: "Journey to Babel")

In 2269, Leonard McCoy suffered hemorrhage of the spleen after being tortured by the Vians. (TOS: "The Empath")

In 2369, Captain Jean-Luc Picard had internal hemorrhaging, as well as liver and spleen damage following an attack by Lenarians. (TNG: "Tapestry")

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