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Senility was a mental deterioration that affected the elderly. Among the more notable victims was Ambassador Sarek just before he died in 2368. (TNG: "Unification I")

In 2369, Els Renora stated to Commander Benjamin Sisko and Ilon Tandro during the trial of the Dax symbiont on Deep Space 9 that she wanted the proceedings to move swiftly and expected to be there until "supper, not senility." (DS9: "Dax")

In 2377, when the USS Voyager was split into 37 timeframes, Commander Chakotay encountered Seska in a timeframe set in 2373, when she and a party of Kazons had temporarily taken control of the ship. In order to bring the ship into sync with normal time, it was necessary to emit a warp pulse, and he tried to enlist her help in doing this. Seska, however, tried to turn the plan to her own advantage and implied that Chakotay had become senile, stating "Men just get more distinguished as they get older. A few lines here, a little grey there, it adds character. Too bad their minds start to go." (VOY: "Shattered")

In the anti-time future, Jean-Luc Picard became inflicted with senility within the 2390s. This impacted his ability to warn others about the anti-time anomaly. (TNG: "All Good Things...")

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