Sector 63 was a region of space. This sector was located near the planet Dytallix B.

In 2364, the starships USS Horatio, USS Renegade USS Thomas Paine and USS Enterprise-D rendezvoused at Dytallix B. Shortly after the ships departed, the Enterprise-D picked up an unusual disturbance in a nearby quadrant, more specifically in Sector 63. The disturbance was caused by the destruction of the Horatio. (TNG: "Conspiracy")