Sector 450 was a region of space.
Prior to stardate 41775, the USS Ganymede and the USS Puget Sound were jointly surveying this sector. Both starship captains received orders from a Starfleet admiral at the Starfleet Mission Operations Division.
In these orders, the captains were advised to avoid Subsectors 4534 to 4432 and to refrain from using high energy sensor scans in Subsector 4418. That order had been supported by Admiral Marcia Meldal-Johnsan and dealt with diplomatic negotiations with the New Zealand government. Both captains were to acknowledge this order on subspace com net security code 045, code 100 alpha. (TNG: "Conspiracy")