Sector 1607 was a region of space located in proximity to both the Romulan Star Empire and the United Federation of Planets. This sector neighbored the sector containing the Mekoria Quasar, and as well, was near the location of where the USS Pegasus disappeared in 2358.

In 2370, the USS Enterprise-D rendezvoused with the USS Crazy Horse in Sector 1607 for the transfer of Admiral Erik Pressman. (TNG: "The Pegasus")