A Sanctuary Processing Center was the entry point for Sanctuary Districts in the United States of America on Earth in the early 21st century.

Residents of the Sanctuary Districts were processed through the Center where their basic information was taken. They were often assigned into three stereoptypical groups: ghosts, dims, and gimmies.

In 2024 the Processing Center for Sanctuary District A in San Francisco was occupied during the Bell Riots and its staff was taken hostage. Among the hostages was Lee, a Public Health official. (DS9: "Past Tense, Part I", "Past Tense, Part II")