Rybotherapy was an experimental treatment developed by neurologist Toby Russell as a potential replacement for leporazine and morathial.

The drug was still in an experimental stage in 2368 when Russell used borathium unsuccessfully to treat a crash victim from the transport ship USS Denver. Dr. Beverly Crusher believed that Russell's use of borathium in that case was a violation of medical ethics, since conventional leporazine therapy might have saved the patient. (TNG: "Ethics")