René Picard was the son of Robert and Marie Picard. He was the nephew of Starfleet Captain Jean-Luc Picard through father Robert.

Like his famous uncle, René had an interest in space exploration. Jean-Luc and René had a particularly close relationship, as a running joke between the two, Jean-Luc referred to René as "uncle" and René referred to Jean-Luc as "nephew". (TNG: "Family")

Tragically, René died in a fire in 2371 at the family home, along with his father. He was survived by his mother. (Star Trek Generations)