A pulse cannon is a type of starship mounted or ground based directed energy cannon weapon.

The Tandaran Detention Complex 26 was defended by pulse cannons. They were the first targets hit by the Enterprise NX-01 shuttlepod piloted by Trip Tucker during his liberation of the camp in late 2151. (ENT: "Detained")

Zobral's desert hideout was protected by pulse cannons. One of them was hit by two attacking Torothan cruisers, during a raid in 2152. (ENT: "Desert Crossing")

In 2370, Quark arranged for the Vulcan gunrunner Sakonna to procure a dozen pulse cannons from the Pygorians for the Maquis. (DS9: "The Maquis, Part II")