(covers information from several alternate timelines)
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Paranoia is an overwhelming fear of one's environment and/or current situation, often leading to illogical responses to various stimuli, however minor.
In 2374 in the alternate timeline known as the "Year of Hell," Lieutenant Tom Paris stated to Commander Chakotay regarding Captain Annorax's belief that time had a personal grudge against him, "That's called paranoia, Chakotay, with a hint of megalomania." (VOY: "Year of Hell, Part II")