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The Pacific Ocean, or the Pacific Basin, was the largest ocean on Earth, comprising a third of its surface area. The Pacific Ocean was the location of several islands and island chains, among them Gravett Island, Midway Island, Wake Island, and Hawaii. The Pacific Ocean was also geographically divided by the International Date Line. Before their extinction in the 21st century, humpback whales lived in this ocean. (TOS: "The Cage", Star Trek IV: The Voyage Home; Star Trek: First Contact)
20th century-era maps of the northern hemisphere Pacific region were stored in the USS Enterprise library computer in 2254. One map depicted the east coast of Asia's USSR nation and Alaska on the west coast of North America. Another map depicted the globe from the point of view of the Arctic Circle, showing the same region. These maps were among the materials viewed by the Talosians when they scanned the Enterprise computer. (TOS: "The Cage")
In 1937 pilot Amelia Earhart and her navigator Fred Noonan disappeared over the Pacific Ocean during an attempt to circumnavigate the Earth. Unknown at the time, Earhart, Noonan and six other humans, were abducted by an alien race known as the Briori and transported to the Delta Quadrant. (VOY: "The 37's")
In an alternate 1944 created by multiple temporal incursions by various factions in the Temporal Cold War, Alicia Travers' husband was serving aboard a destroyer in the Pacific. The ocean itself was pictured on the map of the United States of America that showed the progress of the Nazi's campaign on the American continent. It was described there as Pazifisches Meer. (ENT: "Storm Front")
The Hermosa Earthquake of 2047 struck Southern California, the entire region, including the city of Los Angeles, sank into the Pacific Ocean to a depth of 200 meters, becoming one of Earth's largest coral reefs and home to thousands of different marine species. (VOY: "Future's End")
In 2155, Commander Charles Tucker was able to successfully change the target of the verteron array on Mars, which had been hijacked by John Frederick Paxton, from Starfleet Command to a harmless impact in the Pacific Ocean. (ENT: "Terra Prime")