In the 22nd century, the monastery was ransacked three times by the Andorians looking for a suspected sensor array. On the last of these occasions, in 2151, the Earth starship Enterprise visited P'Jem only to find it taken over by a group of Andorian commandos led by Shran. After some initial misunderstanding and a firefight, the commandos and the Enterprise landing party discovered a highly sophisticated surveillance installation in the catacombs beneath the monastery. Captain Archer gave his science officer's scans of the facility to Shran as evidence of the Vulcans' spying. (ENT: "The Andorian Incident")
Though the Andorians gave the monks and surveillance personnel ample warning before the eventual orbital bombardment, the Vulcan High Command blamed T'Pol, who was by then a subcommander, for allowing Archer to expose the facility and recalled her from Enterprise. They rescinded this decision following T'Pol's actions at Coridan. (ENT: "Shadows of P'Jem")
The repercussions back on Vulcan were longer lasting. The First Minister was dismissed, and the High Command forced the resignation of T'Pol's mother from the Vulcan Science Academy. The evidence of treason they used had been fabricated; even so, T'Pol had no way to restore her mother's position except by marrying into Koss's influential family. (ENT: "Home")
- In the backstory of Star Trek Online, P'Jem was rebuilt by a coalition of Humans, Andorians and Vulcans in 2170. One of the early Federation missions, "Diplomatic Orders", partially takes place there.