Omekla III was a planet in the Cardassian Union on which a minor shipyard was located.

In 2371, Thomas Riker set course for the shipyards at Omekla III after he destroyed Cardassian Outpost 47 with the stolen USS Defiant.

Riker's strategy changed after the ship was damaged by Major Kira Nerys, and the Defiant was forced to take cover in a nebula while undergoing repairs. Following the completion of repairs, the Orias system became the ship's new target. (DS9: "Defiant")