In 2367, Odan came aboard the USS Enterprise-D to mediate negotiations between the two moons of Peliar Zel. Odan had previously mediated between Alpha moon and Beta moon some 30 years before, in the body of a different host. It was hoped that he would be able to accomplish the same results this time and prevent a war between the two. During his efforts Odan refused transport to the surface and insisted on traveling by shuttlecraft. This led to an attack during which the host body was injured, necessitating the removal of Odan.
Odan could not survive more than a few hours outside of a host. A Trill transport was within range and with a suitable host aboard but the Enterprise could not leave Peliar Zel, and the transport was 40 hours away. To extend the life of the symbiont, William T. Riker volunteered to become temporary host. Odan was transferred to his body successfully.
Ultimately Odan was successful in averting a war, but barely in time to prevent permanent harm to the incompatible body of its host, Riker; even before he was extracted, Odan rejected the offer of further immunosuppressants because they would have damaged Riker's body. With negotiations complete Odan was removed and joined to become Kareel Odan.
The transfer of Odan had enormous repercussions. The two factions in the negotiations were initially skeptical of the explanation for Odan's change in appearance and negotiations almost never happened. At the same time, Odan and Doctor Beverly Crusher had begun a relationship prior to his host's injuries. The change in appearance proved professionally and personally difficult for Dr. Crusher; although she had a romantic encounter with Odan while the symbiont was in Riker's body, she broke it off after Odan was transferred into Kareel, as it was too complicated to be involved with someone when they could change bodies so easily.
Both of these reactions can be primarily attributed to the fact that the joined nature of the Trill was not widely known at the time. However, the extremely public and open display of such a surprising secret soon made the joined society of Trill common knowledge. (TNG: "The Host")
- Odan's male host was played by Franc Luz. Kareel, his new host, was played by Nicole Orth-Pallavicini.
- In contrast to the Trill later shown in the series, where the host and the symbiont appear to share consciousnesses, Odan appeared to exert more control over his hosts, as he regularly referred to Riker as a body without any real sign that Riker himself had much impact on Odan's mannerisms or thoughts. However, this could be accounted for by the fact that Riker is the only human we have seen being used as a host for a symbiote, creating the possibility that Odan had to suppress Riker's personality more than he would have done in a Trill host in order to gain the necessary control to complete his mission.
- The Trill featured on Star Trek: Deep Space Nine and in Star Trek: Insurrection would be noticeably different than Odan in both appearance and organization.
- This difference was explained in the non-canon novel Forged in Fire, which explained that the ridged Trill such as Odan's hosts were the result of a strain of the Klingon augment virus that managed to infect a Trill colony through visiting Klingon traders. However, the Trill seemed not to be interested in working on methods of restoring the original Trill look, with this 'sub-group' having recently (at the time the novel was set) been re-accepted back into Trill society. The novel also revealed that Odan's disinclination to use transporters was simply part of a Trill policy to keep the symbiote's existence secret as the transporter scans would have picked it up; presumably, after the public events of the negotiations Odan participated in while in Riker's body, this policy became less relevant, hence accounting for the ease with which Jadzia Dax transported.
- An earlier host of the Odan symbiont appears in Kristine Kathryn Rusch and Jill Sherwin's The Lives of Dax short story "First Steps".
- Crusher encounters Kareel Odan again in a comics story, when she acts as an advisor on the Enterprise-D as it is transporting a Trill master criminal to a new, high-security prison.