The USS Enterprise-D in the Ngame Nebula.
The Ngame Nebula is a nebula located within Federation space. Amongst the star systems within the nebula was a T-Tauri type star with an M-class planet, home to the Paxans.
The USS Enterprise-D passed by the nebula in 2367 enroute to Evadne IV. (TNG: "Clues")