New Berlin Colony was a Federation colony.
In 2354, Benjamin Sisko and his friend Calvin Hudson were posted here. During their time, Benjamin and Jennifer Sisko, together with their friends Cal and Gretchen Hudson, attended a Mazurka Festival. At the festival, people ate sausages and drank beer. Benjamin wore lederhosen and a hat. (DS9: "The Maquis, Part I")
In 2369, the colony had falsely reported a renegade Borg attack in its star system. However, it turned out to be merely a Ferengi trader. (TNG: "Descent")
The colony was either named after the homonymous city on Earth's moon, or after Berlin, a major city on Earth.