A neurolytic restraint was a device used by the Orion Syndicate to ensure obedience in slaves prior to their purchase. The restraint operated by inducing convulsive seizures in the subject through use of a remote control, and was fatal if the subject traveled beyond a specified radius.
In 2154, nine personnel from the Enterprise NX-01 were kidnapped by the Orions and taken to a processing station on Verex III, where they were outfitted with neurolytic restraints as they were being prepared to be auctioned off. Captain Archer purchased Ensign Jeffrey Pierce, and bribed one of the guards to leave the restraint on. After Pierce was returned to Enterprise, Commander Tucker was able to study the restraint and develop a countermeasure against it. Returning to the processing station, Archer disabled all of the restraints, causing mass confusion as the slaves tried to escape, and allowing Archer to rescue his people. (ENT: "Borderland")