The Moselina system is a star system in or near Federation space. The USS Enterprise-D was en route to the Moselina system in 2368 when it diverted to destroy on an asteroid on a collision course with Tessen III.

While underway to the Moselina system after dealing with the asteroid, the Enterprise was to host the wedding of Lwaxana Troi and Minister Campio of Kostolain, but the wedding was canceled. (TNG: "Cost of Living")