Mortar and pestle
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A mortar and pestle was a tool consisting of a bowl and a club-like object used to crush, grind, and mix solid substances.
In 2152, Phlox was mixing ingredients with a mortar and pestle when Travis Mayweather entered sickbay complaining of a headache. (ENT: "Singularity")
In 2268, Leonard McCoy used a mortar and pestle to create a tranquillizer he was planning to use on the Earp gang. (TOS: "Spectre of the Gun")