Melina II was the second planet in the Melina planetary system. The Gray Municipality was located here, as well as two medical installations, the Wiemer Medical Facility and the Taylor Hospital.

This planet was one of eleven visited by a group of Ullian telepathic historians in the 2360s, who collected a library of memories from the inhabitants. There were no reported cases of unexplained comas following their visit. However, several apparent cases of Iresine syndrome were later discovered to have been caused by telepathic memory invasions through the Ullian Jev. (TNG: "Violations")

Melina II appeared in the star chart Data and Picard were studying in stellar cartography in 2371. (Star Trek Generations, display graphic)