(written from a Production point of view)
One of his earliest television appearances was in an episode of the short-lived Superboy, starring fellow DS9 guest performers Salome Jens and Sherman Howard. He went on to appear on such series as MacGyver (in an episode with Time Winters), Seinfeld (starring Jason Alexander and also guest-starring Frank Novak), and NYPD Blue (with Gordon Clapp).
He also has a number of films to his credit, with his first being the major supporting role of Francis Buxton in Pee-wee's Big Adventure (1985), along with fellow DS9 guest star Diane Salinger. He went on to play the role of Chubby in the two Teen Wolf films, the first in 1985 (with Gregory Itzin) and the second, Teen Wolf Too, in 1987. He also made appearances in such major motion pictures as The Naked Gun: From the Files of Police Squad! (1988, with Ricardo Montalban, Tiny Ron and Lawrence Tierney), A League of Their Own (1992, with Ann Cusack and Lori Petty), and The Adventures of Rocky & Bullwinkle (2000) with Jason Alexander, Whoopi Goldberg, Max Grodénchik and Norman Lloyd), as well as the horror movies Leprechaun (1993, with Ken Olandt) and Rumpelstiltskin (1996, with Max Grodénchik and Patrick Massett).
Additional film and TV projects in which Holton appeared with other Star Trek actors include:
- Teen Wolf Too (1987, with Kim Darby, Estee Chandler, Eric Matthew and Star Trek V: The Final Frontier stuntperson David Burton)
- Modern Girls (1986) with Virginia Madsen, Clayton Rohner, and Cameron Thor
- My Chauffeur (1986) with Leland Crooke and Ben Slack
- Flying Blind episode "Panic in Neil's Park" (1993) with Aaron Lustig and Charles Rocket
- My Life (1993) with Kenneth Tigar
- Leprechaun (1993) with Ken Olandt
- Little Giants (1994) with Susanna Thompson
- Hijacking Hollywood (1997) with Scott Thompson
- Navy NCIS episode "Sea Dog" (2003) with Gregory Itzin