Macaroni and cheese was a popular Earth recipe, comprised of a pasta, called macaroni, combined with melted cheese.

In 2024, Benjamin Sisko got a plate of macaroni and cheese along with a slice of bread for Julian Bashir while they were in the Sanctuary District. (DS9: "Past Tense, Part I")

This recipe was once attempted by Neelix. He used an alien substance called brill cheese, made from schplict (grakel milk), that released a dangerous microbe into the life support systems, infecting a bio-neural gel pack with bacteria. (VOY: "Learning Curve")