The Lysian system was a planetary system. A planet in this system, Lysia, was the homeworld of the Lysians, a warp capable species. This inhabited planet was the capital of the Lysian Alliance. It was also the location of the Lysian Central Command. It was protected by 47 Lysian sentry pods around its perimeter.

In 2368, the USS Enterprise-D entered the system while the crew was operating with their memories wiped by the Satarrans. (TNG: "Conundrum")