Lucovexitrin
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Lucovextrin was a substance that wasn't normally picked up by the sensors of a Galaxy-class starship.
Furthermore, along with invidium, saltzgadum, selgninaem, and jakmanite, it was one of only five undetectable substances that can exist in a nitrogen-oxygen atmosphere and can alter the molecular structure of glass.
Lucovexitrin was highly toxic and was thereby ruled out as having caused the malfunctions aboard the USS Enterprise-D at the end of 2366, as the whole crew would have died of poisoning. (TNG: "Hollow Pursuits")