Los Angeles was a city on the Pacific coast of the North American continent. Located in the County of Los Angeles, this southern California city was headed by a mayor. The mayorial offices were located within the historic Los Angeles City Hall. Enforcement of local city ordinances was handled by the Los Angeles Police Department. The city had its own seal, which was seen on police cruisers and official city government papers. (VOY: "Future's End", "Future's End, Part II")
In 1996, the headquarters of Chronowerx Industries were located in Los Angeles. Tuvok commented that the thermal and ultraviolet radiation in California, where the city was located, were at hazardous levels.
After the Hermosa Earthquake of 2047, the entire region sank beneath the water, eventually becoming home to one of Earth's largest coral reefs hosting thousands of different marine species. (VOY: "Future's End", "Future's End, Part II")