The Lorenze Cluster was a region of space containing the planet Minos.
In 2364, the USS Enterprise-D investigated the disappearance of the USS Drake in the Lorenze Cluster. (TNG: "The Arsenal of Freedom")
In early 2365, while the ship was near 'aucdet IX, the Cluster was visible from Ten Forward and was pointed out by Wesley Crusher to Guinan. (TNG: "The Child")
In 2371, the location of the Lorenze Cluster was labeled in the star chart Data and Picard were studying in stellar cartography aboard the USS Enterprise-D. (Star Trek Generations, okudagram)