In the Broken Bow incident of 2151, the Klingon courier Klaang used his disruptor in Broken Bow, Oklahoma, on Earth. In that case, Klaang's disruptor was utilized to destroy a corn silo housing two Suliban agents. (ENT: "Broken Bow")
In 2259 of the alternate reality, Klingon disruptors were used in a battle between a Klingon patrol, an away party from the USS Enterprise and Khan Noonien Singh, a conflict which took place in the Ketha Province on Qo'noS. This style of Klingon disruptor could not only be used to fire at a target, but was also equipped with a double-blade on the front of the barrel and a spiked bottom edge of the handle. (Star Trek Into Darkness)
A Klingon disruptor seen in Star Trek: Enterprise was sold off on the It's A Wrap! sale and auction on eBay.  Klaang's Klingon disruptor from the pilot episode was also sold  and is made from molded foam rubber, painted brown with faux metal accents. It measures 16 × 8 × 3 inches.