Khosla II was the second planet in the Khosla planetary system. This was the place of residence of the Ferengi entrepreneur Plegg, who was largely credited with the invention of holosuite technology, in the late 24th century,.

In 2370, Odo informed Quark of Plegg's whereabouts when Quark attempted to defraud customers into buying counterfeit desiccation discs allegedly containing Plegg's remains. (DS9: "The Alternate")