In 1961, Kennedy gave a famous speech declaring his intentions of making the United States of America the first nation on Earth to go to the moon. An image depicting Kennedy's speech was scanned by the Talosians as they reviewed the library computer files on board USS Enterprise in 2254. (TOS: "The Cage" remastered) A quote from this speech appeared on the USS Valiant's dedication plaque: "We set sail on this new sea because there is new knowledge to be gained and new rights to be won." (DS9: "Valiant")
|Selected Presidents of the United States of America|
|George Washington (1789) • Thomas Jefferson (1801) • Andrew Jackson (1829) • Abraham Lincoln (1861) • Ulysses S. Grant (1869) • Theodore Roosevelt (1901) • Woodrow Wilson (1913) • Franklin D. Roosevelt (1933) • Harry S. Truman (1945) • Dwight D. Eisenhower (1953) • John F. Kennedy (1961) • Lyndon B. Johnson (1963) • Richard M. Nixon (1969) • Jimmy Carter (1977) • Ronald Reagan (1981) • George H.W. Bush (1989) • William J. Clinton (1993) • George W. Bush (2001) • ...|
In the script of the Star Trek: Deep Space Nine episode "The Homecoming", the writers likened the Bajoran response to the arrival of Li Nalas to Deep Space 9 to that of a hypothetical re-appearance of JFK thirty years after his assassination. The script states that "it's as if JFK had survived Dallas and suddenly appeared on a public street 30 years later".
The Star Trek teaser trailer uses a portion of Kennedy's 1961 speech ("The eyes of the world now look into space.") Co-writer Roberto Orci argued Kennedy was an influence on the original character of James T. Kirk. 
Gene Roddenberry saw a plot for the early drafts of Star Trek II: The Wrath of Khan, Star Trek III: The Search for Spock, and Star Trek IV: The Voyage Home where the Enterprise crew went back in time to stop the Klingons from stopping JFK's assassination. (citation needed • edit)