The Hupyrian beetle was a type of insect native to the Hupyrian homeworld.

Hupyrian beetles were the main ingredient of Hupyrian beetle snuff.

In 2371 Quark's mother Ishka took part of the monthly stipend Quark sent her and invested it in a high-quality Hupyrian beetle farm. She made three bars of gold-pressed latinum. (DS9: "Family Business")

Two years later, the Grand Nagus Zek allocated extra funds for research on a new breed of Hupyrian beetles hoping that the new breed would revolutionize the entire beetle snuff industry. (DS9: "Ferengi Love Songs")