Handcuffs, known colloquially as irons or cuffs, are a type of restraint that limit an individual's wrist movement.
In 2151, a team of Ferengi successfully subdued the crew of Enterprise NX-01 and boarded the ship with the intent on stealing anything of value. After they were unable to locate a vault, they revived Captain Jonathan Archer to question him, but not before handcuffing him to a bulkhead to prevent his escape. (ENT: "Acquisition")
In 2268, Captain James T. Kirk threatened to hold Federation Undersecretary for Agriculture Nilz Baris in irons if he did not "shut up" and cease his complaints about Kirk's actions at Deep Space Station K-7. (TOS: "The Trouble with Tribbles")
In 2293, Klingon General Chang ordered the arrest of Captain Kirk and Doctor Leonard McCoy for the assassination of Chancellor Gorkon. They were subsequently placed in handcuffs until their trial, however it was later revealed that Chang had orchestrated the whole event, and they were released of all charges. (Star Trek VI: The Undiscovered Country)
In 2372, during the Julian Bashir, Secret Agent holoprogram, Doctor Bashir, as Patrick Merriweather, used his charm to convince Doctor Honey Bare, who was imbued with the body of Jadzia Dax due to an transporter accident, to give him her hairpin. He then used it to undo the handcuffs binding him and Elim Garak at the time. (DS9: "Our Man Bashir")
In 2373, Captain Benjamin Sisko forced Maquis leader Michael Eddington to accompany him a Template:ShipClass runabout to stop several missiles that were supposedly heading for Cardassian space. During their time on the runabout, the Captain ensured Eddington remained in his handcuffs though later took them off him during a firefight with Jem'Hadar forces. (DS9: "Blaze of Glory")
In 2374, Doctor Julian Bashir was handcuffed and paraded down the Promenade of Deep Space 9 to the security office, during Luther Sloan's holographic recreation of the station. The holographic representation of Captain Sisko protested, claiming a Starfleet officer shouldn't be dragged across the Promenade in irons. (DS9: "Inquisition")