Grid 216 is the Borg designation for a region of space in the Delta Quadrant, near the Kesat homeworld. It is the location of a large Ba'neth outpost, hidden by a cloaking field.

In 2376, the USS Voyager confronted the Ba'neth in Grid 216 to obtain information on a weapon that had caused severe neurological damage to Lieutenant Commander Tuvok. (VOY: "Riddles")