Giuseppina Pentangeli was a female Human opera singer, considered to be the greatest soprano of the 22nd century.

In 2373, The Doctor performed the duet O, Soave Fanciulla with a holographic re-creation of Giuseppina Pentangeli. However, the hologram of Pentangeli also duplicated her vanity and demanding temperament. The Doctor insulted her when he told her that she was rushing the tempo. She called him an amateur and told him he knew nothing about opera. The Doctor considered singing with Maria Callas next time instead. (VOY: "The Swarm")