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Frankenstein was a novel written by Mary Shelley in the early 19th century. The book depicted a scientist named Dr. Frankenstein who infused life into an inanimate corpse, described as "Frankenstein's monster", consisting of Human body parts with the power of electricity.

During the mid-20th century, the book inspired at least four films: Frankenstein, Bride of Frankenstein, Son of Frankenstein, and Abbott and Costello Meet Frankenstein. (ENT: "Horizon")

When Wesley Crusher worked overtime on one of his science projects, nanites, he stated, that it was "just a science project." Guinan commented "A doctor friend once said the same thing to me. Frankenstein was his name." Wesley later stated that he always got an A, whereupon Guinan said "So did Doctor Frankenstein." (TNG: "Evolution")

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The Star Trek: The Next Generation seventh season episode "Thine Own Self" was inspired by Frankenstein. (Star Trek: The Next Generation Companion (2nd ed., p. 283))

Christian Ford and Roger Soffer's story pitch that became DS9: "Life Support" was based on Frankenstein. (Star Trek: Deep Space Nine Companion (p. 204))

The various "kitbashed" starships, composed of parts from other ships, seen in the background of various episodes of Star Trek: Deep Space Nine were sometimes referred to as the "Frankenstein fleet".

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