In early history, a band of marauders based on Triacus wreaked chaos on the inhabitants of the Epsilon Indi system. After many centuries of intrusion, the inhabitants of Epsilon Indi were finally able to rise up and destroy the marauders, leading to their corporeal extinction. (TOS: "And the Children Shall Lead")
In 2364, the location of Epsilon Indi was named in a star chart of a stellar neighborhood with Sol at the center. This chart was stored in the USS Enterprise-D library computer. Later that year, the chart was scanned by the Portal of Portal 63. (TNG: "The Naked Now", production art; TNG: "The Last Outpost")
The star chart naming stars within 20 light years of Sol was drawn by Rick Sternbach for the Star Trek Spaceflight Chronology in the late 1970s. Found on page 77, this chart showed Earth commercial and exploration routes after the use of warp drive began.
According to the Star Fleet Technical Manual, the Star Empire of Epsilon Indii was one of the founding members of the Federation. The eighth planet of the Epsilon Indi was stated to be Andor, the homeworld of the Andorian race in The Worlds of the Federation.
According to Star Trek: Star Charts, Epsilon Indi (Draylax) was located in the Beta Quadrant. One of the planets in this system was named Draylax. In the mid-22nd century, this system was named as a stop on the Earth trade routes. Epsilon Indi was classified as a K class star. It had a magnitude of +7, which was 1/10 as bright as Sol.