The Dreon system is a star system in Federation space. The border between the Federation and Cardassian Union runs along this system, which itself is located near the Badlands. The Rolor Nebula and the Panak sector are also in close proximity to this system.
In 2372, Kasidy Yates claimed to be making visits to the Dreon system to deliver medical supplies to the Tholians, an oddity since the Dreon system is a good distance away from Tholian space. In actuality, however, she was supplying materials to the Maquis. (DS9: "For the Cause")