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Director is a term for a person responsible for an organization or facility.
From 2257 to 2266, Anton Karidian was the director of the Karidian Company of Players. (TOS: "The Conscience of the King")
In 2266, Dr. Tristan Adams was the director of the rehab colony on Tantalus V. His associate, Dr. Simon Van Gelder, was promoted to co-director of this facility within six months of being assigned there. After he was treated for neuro-synapse damage caused by the neural neutralizer, Van Gelder returned to the colony as director. (TOS: "Dagger of the Mind")
Doctor Howard Clark served as the director of the Federation science station based on Ventax II. (TNG: "Devil's Due")
Doctor Berel served as director of the Sikla Medical Facility on the planet Malcor III. (TNG: "First Contact")
Lewis Zimmerman was the Director of Holographic Imaging and Programming at Jupiter Station in the 2370s. (DS9: "Doctor Bashir, I Presume")
The Cardassian Institute of Art had a Director. Tora Ziyal spoke to him in 2374 about her desire to have her paintings displayed. (DS9: "Sons and Daughters")